The hunters return to the Florida Everglades to find a new generation of pythons more formidable than ever. With the enemy multiplying, the teams add firepower--and call upon local legends for reinforcements.

Troy and Pickle call in a chopper to reach a remote hunting spot deep in the Everglades. Zak and Aaron attempt a bold new strategy using fish chum to attract snakes.

The teams unite to storm a hostile site that's rumored to be swarming with pythons. Attacking by land, water and air, the teams deploy buggies, boats and drones to target and eliminate a growing threat to the Everglades.

Troy and Pickle struggle to take command of a friend's hunting dog. Zak and Aaron deploy kayaks deep into an untested area. Bruce and Kaylyn explore an isolated island with a gruesome past.

As the excessive heat begins to wear on the hunters, the King of the Swamp launches a contest to catch the biggest python. Each hunting team uses their local knowledge to devise different strategies, hoping to come home the winner.

Pickle learns to drive an airboat on the fly; Zak and Aaron go after two invasive species at once; Bruce and Kaylyn fight through skin-shredding sawgrass; Dusty tests recipes for a new Everglades culinary sensation.

The hunters push past the point of exhaustion in the final stretch of python season, tempting fate in panther country, gambling on isolated hotspots, and searching into the dead of night.

In the final hunt of the year, the hunters descend on Florida's pristine Lake Elizabeth wetlands and go to battle with pythons gaining a foothold in this vital ecosystem, pushing their limits to safeguard paradise.